L-Norvaline is an analog of the amino acid L-valine. Research shows that L-norvaline is a strong inhibitor of arginase activity because of its structural similarity to ornithine, which causes a feedback regulation on the activity of arginase. When you inhibit arginase, NO is produced continuously at a higher rate in the presence of NOS and adequate L-arginine. L-arginine is the limiting factor for NO production from NOS, so inhibiting the arginase enzyme effectively increases the production of NO by as much as 60%.

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